Study Search

• Network-based Drug Repurposing for Human Coronavirus.
  Zhou Y, Hou Y, Shen J, Huang Y, Martin W, Cheng F
  Human Coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle east respiratory syndrome coronavirus (MERS-CoV), and 2019 novel coronavirus (2019-nCoV), lead global epidemics with high morbidity and mortality. However,…
• One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and nitrogen species?
  Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ
  Melatonin is a highly conserved molecule. Its presence can be traced back to ancient photosynthetic prokaryotes. A primitive and primary function of melatonin is that it acts as a receptor-independent…
• Ebola virus disease: potential use of melatonin as a treatment.
  Tan DX, Korkmaz A, Reiter RJ, Manchester LC
  The purpose of this report is to emphasize the potential utility for the use of melatonin in the treatment of individuals who are infected with the Ebola virus.
• Mitochondria: the birth place, battle ground and the site of melatonin metabolism cells.
  Tan DX , Reiter RJ
  It was a surprising discovery when mitochondria, as the power houses of cells, were also found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin synthetic enzyme serotonin N-acetyltransferase…
• Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction.
  Ressmeyer AR, Mayo JC, Zelosko V, Sáinz RM, Tan DX, Poeggeler B, Antolín I, Zsizsik BK, Reiter RJ, Hardeland R
  In numerous experimental systems, the neurohormone melatonin has been shown to protect against oxidative stress, an effect which appears to be the result of a combination of different actions. In…
• Treatment of Ebola and other infectious diseases: melatonin “goes viral”.
  Reiter RJ, Sharma R
  This review summarizes published reports on the utility of melatonin as a treatment for virus-mediated diseases. Of special note are the data related to the role of melatonin in influencing…
• Melatonin in Mitochondria: Mitigating Clear and Present Dangers.
  Reiter RJ, Ma Q, Sharma R
  In cancer cells, glucose is primarily metabolized to pyruvate and then to lactate in the cytosol.
• Melatonin as an antioxidant: under promises but over delivers.
  Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L
  Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large number of circumstances. It achieves this action via a variety of means: direct detoxification of reactive oxygen and…
• Melatonin as a mitochondria-targeted antioxidant: one of evolution’s best ideas.
  Reiter RJ, Rosales-Corral S, Tan DX, Jou MJ, Galano A, Xu B
  Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been retained throughout evolution such that it may be or may have been present in every species…
• Test study all categories
  Author XY
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• Melatonin in bacterial and viral infections with focus on sepsis: a review.
  Srinivasan V, Mohamed M, Kato H
  Melatonin is a versatile molecule, synthesized not only by the pineal gland, but also in small amounts by many other organs like retina, gastrointestinal tract, thymus, bone marrow, lymphocytes etc.
• Melatonin: its possible role in the management of viral infections – a brief review.
  Silvestri M, Rossi GA
  Melatonin, a versatile molecule, is synthesized by the pineal gland but also by other organs, including gastrointestinal tract, retina, thymus, bone marrow, and by leukocytes.
• Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks.
  Hardeland R
  Aging and various age-related diseases are associated with reductions in melatonin secretion, proinflammatory changes in the immune system, a deteriorating circadian system, and reductions in sirtuin-1 (SIRT1) activity. In non-tumor…
• Melatonin-immune system relationships.
  Guerrero JM , Reiter RJ
  In this paper we review the historical milestones that first highlighted the existence of a relationship between melatonin and the immune system and we summarize data from experiments which correlate…
• On the free radical scavenging activities of melatonin’s metabolites, AFMK and AMK.
  Galano A, Tan DX, Reiter RJ
  The reactions of N(1) -acetyl-N(2) -formyl-5-methoxykynuramine (AFMK) and N(1) -acetyl-5-methoxykynuramine (AMK) with (•) OH, (•) OOH, and •OOCCl3 radicals have been studied using the density functional theory.
• Melatonin: buffering the immune system.
  Carrillo-Vico A, Lardone PJ, Alvarez-Sánchez N, Rodríguez-Rodríguez A, Guerrero JM
  Melatonin modulates a wide range of physiological functions with pleiotropic effects on the immune system.
• Melatonin: A new inhibitor agent for cervical cancer treatment.
  Shafabakhsh R, Reiter RJ, Mirzaei H, Teymoordash SN, Asemi Z
  Cervical cancer is one of the most common cancers between women and is known as the third leading cause of female cancer related deaths annually. Its detection in early stages…
• Melatonin: action as antioxidant and potential applications in human disease and aging
  Bonnefont-Rousselot D , Collin F
  This review aims at describing the beneficial properties of melatonin related to its antioxidant effects. Oxidative stress, i.e., an imbalance between the production of reactive oxygen species and antioxidant defences,…
• Beneficial actions of melatonin in the management of viral infections: a new use for this “molecular handyman”?
  Boga JA, Coto-Montes A, Rosales-Corral SA, Tan DX, Reiter RJ
  Melatonin (N-acetyl-5-methoxytryptamine) is a multifunctional signaling molecule that has a variety of important functions. Numerous clinical trials have examined the therapeutic usefulness of melatonin in different fields of medicine.
• Ebola virus: melatonin as a readily available treatment option
  Anderson G, Maes M, Markus RP, Rodriguez M
  There is currently an urgent need for a viable, cheap, and readily available treatment for the Ebola virus outbreak in West Africa. Here, it is proposed that melatonin may have…

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